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KMID : 0370219820260040197
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Yakhak Hoeji
1982 Volume.26 No. 4 p.197 ~ p.208
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Influence of Mori Radicis Cortex on the Renal Function of Dog
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高錫太/Ko, Suk Tai
李殷和/Lee, Eun Wha
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Abstract
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In this study attemps were made to obtain evidence as to the action of Mori Radicis Cortex on the renal? functicn of anesthetized mongrel dogs. 1. A light brown powder isolated from Mori Radicis Cortex (MRC) by a slight modification of Tanemura´s method, when given intravenously in doses ranging 0.5 to 5. 0mg/kg, elicited diuresis with the increase of positive water clearance and amounts of Na+ and K+ excreted in the urine. At this time the glomerular filtration rate, renal plasma flow and osmolar clearance were not observed to have any significant changes. This diuresis was augmented in process of time and its maximum effect was exhibited about 36 minutes after administration of MRC. 2. The MRC, when administered into a intra carotid artery, responded promptly with diuresis and natriuresis at a level too small to effect renal functions when administered intravenously. In this experiment the patterns of changes of renal function were the patterns of changes of renal function wcre the same as those of the above intravenously administered experiment. 3. When infused directly into a renal artery, the MRC exhibited little effect on either kidney. 4. During water diuresis, the MRC did not elicit diuretic action or significant changes in renal functions. The above observations suggest that the diuresis of MRC is brought about by the inhibition of the release of antidiuretic hormone with the mechanism facilitating the excretion of Na+ and K+ in urine.
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